Lighting on the M6 between junctions 15 and 16 near Stoke-on-Trent will be switched off from next Thursday.
The Highways Agency said the stretch of motorway has a good safety record and the lights can be switched off without increasing risks to road user safety.
Tim Harbot, Midlands Regional Director for the Highways Agency, said: “Since 2009 we’ve switched lighting off between the hours of midnight and 5am on 15 carefully selected stretches of motorways.
“This includes some stretches of lighting on the M5 and the M54 in the West Midlands.
“Evidence so far indicates that switching off the lights hasn’t had an impact on safety. Analysis also suggests that switching off lights does not appear to have affected traffic volumes or speed.
“This is not about wishing to remove all lights from the motorway network, but we are confident we can now begin to permanently switch off motorway lights at certain sites.
“It’s about carefully identifying the locations where, under the revised guidelines, we would not consider installing lighting.
“On this stretch of the M6, we expect to reduce annual carbon emissions by about 148 tonnes. Local communities will benefit from reduced light pollution of the night sky.
“We will also use the money we save elsewhere on the strategic road network where it would have a more significant safety benefit and potentially save more lives.”